She was friends with Dan Connor during high school and had a sexual interest in him, he was however dating Roseanne Conner at the time. She was in Roseanne's and Dan's class and was often the main focus of talent shows, much to Jackie's annoyance.
Shortly after graduation, she traveled to Chicago to play with her garage band. She stayed there for 30 years, living off of her success. A few months after Roseanne's death though, she finds herself living back in Lanford. She reveals her feelings for Dan, but is rejected due to him still being in love with his wife, they decide to continue to remain close friends thereafter.
After Becky has her baby, Louise and Dan make the decision to hang out more and see where things eventually lead to. This has caused pain for Jackie who is still grieving over Roseanne. However, Louise promised her to take it slowly and not marry him unless Jackie decides it is okay. After time though, Louise begins to grow tired of Dan not wanting to take it to the next level and thinks he's just stringing her along. Dan isn't willing to moving on, and Louise decides she's had enough and leaves Dan.
In 2020, Louise goes on tour again, leaving Casita Bonita to an endlessly working Becky. During her tour though, Dan comes to finally confess his love for her, only to see her kissing a man called Zach. After Dan tells Zach about his love for her, Zach ends up telling Louise about it, much to her annoyance, she comes back to Lanford to confront Dan about it. Louise demands she confesses his love for her directly to her face, which he eventually does, and they decide to begin officially dating.
List of Appearances